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Author by: Giovanni GuareschiLanguange: enPublisher by: Don Camillo SeriesFormat Available: PDF, ePub, MobiTotal Read: 84Total Download: 879File Size: 40,9 MbDescription: More timeless, bittersweet stories of life in Italy's Lower Plain, most of which appear in English for the first time. They begin, as the last collection ended, with Don Camillo in exile in the mountains, But it isn't long before this lightning conductor for problems in the Little World draws Peppone and all human nature to his door. Author by: Alan R. PerryLanguange: enPublisher by: University of Toronto PressFormat Available: PDF, ePub, MobiTotal Read: 84Total Download: 894File Size: 53,7 MbDescription: Giovannino Guareschi (1908-1968) was an Italian journalist, humorist, and cartoonist best known for his short stories based on the fictional Catholic priest Don Camillo. In this study, Alan R. Perry explores the Don Camillo stories from the perspective of Christian hermeneutics, a unique approach and the best critical key to unlocking the richness of both the author and his tales. The stories of Don Camillo, the cantankerous but beloved priest, and his sidekick, Communist mayor Peppone, continue to entertain viewers and readers.

Their Cold War adventures, mishaps, arguments, and reconciliations have a timeless quality, and their actions reflect endearing values that prevail even today. The stories delight, to be sure, but the best of them also force us to stop and think about how Guareschi so powerfully conveyed the Christian message of faith, hope, and love. To appreciate the true genius of Guareschi, Perry argues that we must delve deeper into the latent spiritual meaning that many of his stories contain. In reflecting popular understandings of the faith, the Don Camillo tales allow us to appreciate a sacred awareness of the world, an understanding communicated through objects, gestures, expressions, and actual religious rites. The first full-length scholarly examination of the Don Camillo stories to appear, this book offers a solid appreciation of Italian cultural values and discusses the ways in which those values were contested in the first decades of the Cold War. Author by: Gino MoliternoLanguange: enPublisher by: Scarecrow PressFormat Available: PDF, ePub, MobiTotal Read: 55Total Download: 501File Size: 43,5 MbDescription: The Italian cinema is regarded as one of the great pillars of world cinema.

Films like Ladri di biciclette (1948), La dolce vita (1960), and Nuovo cinema Paradiso (1988) attracted unprecedented international acclaim and a reputation, which only continue to grow. Italian cinema has produced such acting legends as Sophia Loren and Roberto Benigni, as well as world-renowned filmmakers like Federico Fellini, Sergio Leone, Mario Bava, Dario Argento, and Lina WertmYller, the first woman to ever be nominated for the Best Director award.

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The A to Z of Italian Cinema provides a better understanding of the role Italian cinema has played in film history through a chronology, an introductory essay, a bibliography, appendixes, black-&-white photos, and hundreds of cross-referenced dictionary entries on actors, actresses, movies, producers, organizations, awards, film credits, and terminology. Author by: Thomas J.

Edward WalkerLanguange: enPublisher by: Lexington BooksFormat Available: PDF, ePub, MobiTotal Read: 82Total Download: 599File Size: 45,6 MbDescription: Illusive Identity is a transnational exploration of the evolution of working-class consciousness within modern Western culture. The work traces how the rise of popular culture blurred the definition and dulled the influence of class identity in Europe and the United States in the nineteenth and early twentieth centuries. Chapters tackling changing class consciousness in Britain, Germany, Italy, and the United States offer rich insight into the movement from a traditional community-based social identity to a modern consumer-based culture; a mass culture influenced by industrialization, new social institutions, and the powerful imagery of new media. Illusive Identity vividly demonstrates the transformative impact of modernity on the laboring classes, as advertising, entertainment, and the rise of the popular press replaced traditionally shared narratives about the nature of work with a new and liberating cultural paradigm. Author by: Pamela PaulLanguange: enPublisher by: Henry Holt and CompanyFormat Available: PDF, ePub, MobiTotal Read: 45Total Download: 350File Size: 41,5 MbDescription: Sixty-five of the world's leading writers open up about the books and authors that have meant the most to them Every Sunday, readers of The New York Times Book Review turn with anticipation to see which novelist, historian, short story writer, or artist will be the subject of the popular By the Book feature. These wide-ranging interviews are conducted by Pamela Paul, the editor of the Book Review, and here she brings together sixty-five of the most intriguing and fascinating exchanges, featuring personalities as varied as David Sedaris, Hilary Mantel, Michael Chabon, Khaled Hosseini, Anne Lamott, and James Patterson.

The questions and answers admit us into the private worlds of these authors, as they reflect on their work habits, reading preferences, inspirations, pet peeves, and recommendations. By the Book contains the full uncut interviews, offering a range of experiences and observations that deepens readers' understanding of the literary sensibility and the writing process. It also features dozens of sidebars that reveal the commonalities and conflicts among the participants, underscoring those influences that are truly universal and those that remain matters of individual taste.

For the devoted reader, By the Book is a way to invite sixty-five of the most interesting guests into your world. It's a book party not to be missed.

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›The Little World of Don Camillo. Giovanni Guareschi. Translated by Una Vincenzo Troubridge. Contributions very highly — perhaps because I am editor-in-chief.

A few months ago the leader of the. Mind, you will easily come to know the village priest, Don Camillo, and his adversary, Peppone, the Communist. The Little World of Don Camillo (Don Camillo Series Book 1) - Kindle edition by Giovanni Guareschi, Piers Dudgeon, Adam Elgar. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading The Little World of Don Camillo (Don Camillo.Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats.

Original Article A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis Ludwig Kappos, M.D., Ernst-Wilhelm Radue, M.D., Paul O'Connor, M.D., Chris Polman, M.D., Reinhard Hohlfeld, M.D., Peter Calabresi, M.D., Krzysztof Selmaj, M.D., Catherine Agoropoulou, Ph.D., Malgorzata Leyk, Ph.D., Lixin Zhang-Auberson, M.D., Ph.D., and Pascale Burtin, M.D., Ph.D., for the FREEDOMS Study Group N Engl J Med 2010; 362:387-401 DOI: 10.1056/NEJMoa0909494. Methods In our 24-month, double-blind, randomized study, we enrolled patients who had relapsing–remitting multiple sclerosis, were 18 to 55 years of age, had a score of 0 to 5.5 on the Expanded Disability Status Scale (which ranges from 0 to 10, with higher scores indicating greater disability), and had had one or more relapses in the previous year or two or more in the previous 2 years.Patients received oral fingolimod at a dose of 0.5 mg or 1.25 mg daily or placebo. End points included the annualized relapse rate (the primary end point) and the time to disability progression (a secondary end point). Results A total of 1033 of the 1272 patients (81.2%) completed the study. The annualized relapse rate was 0.18 with 0.5 mg of fingolimod, 0.16 with 1.25 mg of fingolimod, and 0.40 with placebo (P. Figure 1 Enrollment, Randomization, and Follow-up of Study Patients.Among the 292 patients who were assessed for eligibility but were not enrolled, some were excluded for more than one reason. For one patient receiving 1.25 mg of fingolimod daily who completed the study while receiving the study drug, the status was incorrectly recorded by the investigator as having discontinued the study while still receiving the study drug.Patients who discontinued the study drug include those who discontinued the study; the correct status is shown here.

Figure 2 Study End Points, According to Study Group.Panel A shows Kaplan–Meier estimates for the time to a first relapse, and Panel B shows Kaplan–Meier estimates for the time to disability progression, confirmed after 3 months, as measured with the Expanded Disability Status Scale (EDSS). Panel C shows the proportions of patients free from gadolinium-enhancing lesions and the mean (±SD) number of gadolinium-enhancing lesions at baseline and at 6, 12, and 24 months.

Data on gadolinium-enhancing lesions were available for 416 patients assigned to receive placebo, 424 assigned to receive 1.25 mg of fingolimod, and 424 assigned to receive 0.5 mg of fingolimod, respectively, at baseline; 373, 388, and 403, respectively, at 6 months; 356, 376, and 394, respectively, at 12 months; and 332, 343, and 369, respectively, at 24 months. The P values for the proportions were obtained with the use of a logistic-regression model, with adjustment for study group, country, and number of lesions at baseline. Fingolimod (FTY720) is an oral sphingosine-1-phosphate–receptor modulator that is currently being evaluated for the treatment of multiple sclerosis.There is evidence that fingolimod acts by preventing lymphocyte egress from lymph nodes.

This leads to a reduced infiltration of potentially autoaggressive lymphocytes into the central nervous system. Preclinical findings also suggest that fingolimod may promote neuroprotective and reparative processes within the central nervous system through modulation of sphingosine-1-phosphate receptors expressed on neural cells. A 6-month, phase 2, placebo-controlled study and its open-label extension study showed sustained suppression, for up to 5 years, of both relapse and inflammatory activity in patients receiving fingolimod. Furthermore, in a recently completed, 12-month, phase 3 study involving patients with relapsing–remitting multiple sclerosis (TRANSFORMS Trial Assessing Injectable Interferon vs.FTY720 Oral in RRMS; ClinicalTrials.gov number, NCT00340834), reported elsewhere in this issue of the Journal, fingolimod reduced the relapse rate and disease activity as measured with the use of magnetic resonance imaging (MRI), as compared with a once-weekly, intramuscular injection of interferon beta-1a at a dose of 30 μg. In our phase 3, double-blind, placebo-controlled study, called FREEDOMS (FTY720 Research Evaluating Effects of Daily Oral therapy in Multiple Sclerosis), we investigated the effects of daily fingolimod treatment for 24 months on the relapse rate, disability progression, and MRI measures of inflammation, burden of disease, and tissue destruction in patients with relapsing–remitting multiple sclerosis. Study Oversight Steering-committee members (listed in the, available with the full text of this article at NEJM.org) collaborated with the sponsor, Novartis Pharma, to develop the protocol and monitor the ongoing study. Data were collected by the investigators and analyzed by the sponsor.

All the authors had access to the data, participated in the data analysis and interpretation, and wrote the manuscript. All authors vouch for the accuracy and completeness of the data and the statistical analysis.

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All authors participated in the writing of the manuscript and approved the final manuscript before submitting it for publication.Patients Key eligibility criteria were an age of 18 to 55 years; a diagnosis of multiple sclerosis, according to the revised McDonald criteria; a relapsing–remitting course; one or more documented relapses in the previous year or two or more in the previous 2 years; and a score of 0 to 5.5 on the Expanded Disability Status Scale (EDSS; which ranges from 0 to 10, with higher scores indicating greater disability). Key exclusion criteria were relapse or corticosteroid treatment within 30 days before randomization, active infection, macular edema, diabetes mellitus, immune suppression (drug- or disease-induced), or clinically significant systemic disease.Interferon-beta or glatiramer acetate therapy had to have been stopped 3 or more months before randomization.

The study was conducted in accordance with the International Conference on Harmonisation Guidelines for Good Clinical Practice and the Declaration of Helsinki. The protocol was approved by each site's institutional review board; patients gave written informed consent before any study-related procedures were performed.

Study Design and Randomization Patients were randomly assigned, in a 1:1:1 ratio, to receive oral fingolimod capsules in a dose of 0.5 mg or 1.25 mg or matching placebo, once daily for 24 months. Randomization was performed centrally, with the use of a validated system and stratification according to site, with a block size of six within each site.Study Procedures and End Points Clinical assessments were performed at screening and at randomization (baseline), and study visits, including safety assessments, were scheduled at 2 weeks and 1, 2, 3, 6, 9, 12, 15, 18, 21, and 24 months after randomization. The EDSS score was determined every 3 months, and the MSFC z score every 6 months. Standardized MRI scans were obtained at the screening visit and at 6, 12, and 24 months and were analyzed centrally at the Multiple Sclerosis–MRI Evaluation Center at the University Hospital in Basel, Switzerland. The primary end point was the annualized relapse rate, defined as the number of confirmed relapses per year. Relapses were verified by the examining neurologist within 7 days after the onset of symptoms. To constitute a confirmed relapse, the symptoms must have been accompanied by an increase of at least half a point in the EDSS score, of one point in each of two EDSS functional-system scores, or of two points in one EDSS functional-system score (excluding scores for the bowel–bladder or cerebral functional systems).